The genetic information of an organism, known in whole as the genome, is a fundamental and vital part of its existence and survivability. The favorable evolution of an organism is its innate ability to mutate its present set of fixed genetic composition with possible variations present in its genome. Such genetic mutation when performed by man, in vitro, with the intention to induce a specific desired characteristic, is called genetic editing. The field of performing successful genomic editing is commonly referred to as genetic engineering. To construct an organism capable of exhibiting desired characteristics one requires genome editing practices that involve small microorganisms, preferably viruses. Today viruses are most commonly used vectors for gene insertion and modification.
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Based on their application, genetic engineering can be segmented into animal genome engineering, plant genome engineering and in-vitro cell-line engineering. Animal genome engineering services monitors hybrids/crossbreeds/thoroughbreds in order to select and amplify the desired trait that serves a particular purpose. In horse breeding, animal genetics help stud (male race horse) farm owners to select racing breed and experiment among thoroughbreds, thereby gaining a fine genotype for horse racing. Similarly, plant genome engineering process is required to identify certain characteristics in plant species and perform selective genome expression and breeding. In vitro cell-line engineering services provide life science businesses with optimized genotype; refined biological by products and cell extracts. Cell line engineering reduces the requirement for traditional breeding and increases the exhibition of required characteristics such as protein secretion, enzyme production, cell composite production, metabolism of compounds, and others.
Based on technology, genome engineering services include engineered nucleases such as zinc finger nuclease, transcription activator-like effector nucleases (TALEN), clustered regularly interspaced short palindromic repeats (CRISPR’s), and random gene insertion methods.
Based on end users, genome engineering services are offered to industries such as biotechnology companies, agriculture industry, food processing companies, pharmaceutical companies, CRO’s, and research laboratories.
Geographically the genome engineering/editing market is primarily concentrated in the North American region. The North American meat industry is among the largest in the world followed by European and Asia Pacific region. The crop and cattle industry forms the largest consumer of genome engineering services in the region, followed by equine, and canine breeding industry. On the other hand European companies continue to remain a strong point in the global genetic services market mainly due to high quality of services offered and their increased reliability. The European Commission has funded the Sustainable Animal Breeding (SABRE) program with 14 million Euros and expects it to complete by 2025. The program is expected to sequence the genome of pigs and other farm animals. However, numerous restrictions for genome engineering in the European and North American region continue to hamper the growth of the genome engineering services. The demand for genetics based services in the Asia Pacific region is expected to grow during the forecast period from 2014 to 2022. Australia, Japan, and China form the largest market in the Asia Pacific region. South Asia and South East Asia on the other hand show great potential in terms of genetics application, although at present a majority of genome engineering process is done by breeding. The genome engineering market in the Rest of the World (ROW) is expected to grow at a steady rate, albeit slower than the major economies of the world.
Some of the well known genome engineering laboratories in the world include: Animal Genetics Inc., EW – Erich Wesjohann Gruppe, Genus PLC, Grimaud Groupe, Monsanto Company, E. I. du Pont de Nemours and Company, Harlan Laboratories Inc., Hendrix Genetics B.V, KWS AG Koepon Holding, Bayer Crop Science Lohmann Animal Health, Syngenta AG, PHW Gruppe, The Grimaud Group, Takii & Co Ltd etc to name a few.
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